Contact angles on heterogeneous surfaces; a new look at Cassie's and Wenzel's laws

We consider a three dimensional liquid drop sitting on a rough and chemically heterogeneous substrate. Using a novel minimization technique on the free energy of this system, a generalized Young's equation for the contact angle is found. In certain limits, the Cassie and Wenzel laws, and a new equivalent rule, applicable in general, are derived. We also propose an equation in the same spirit as these results but valid on a more `microscopic' level. Throughout we work under the presence of gravity and keep account of line tension terms.Comment: 10 pages RevTeX, 2 EPS figures. A few minor corrections mad

Wetting between structured surfaces: Liquid bridges and induced forces

Wetting phenomena are theoretically studied for a slab geometry consisting of a wetting phase confined between two chemically patterned substrates. Each of these is decorated by an array of stripes whose composition alternates between two different surface phases. For a single pair of opposing stripes, the wetting phase may either form a bridge spanning from one surface to the other or it may break up into two separate channels. The bridge state induces an effective interaction between the two substrates. This leads to the bridge itself having a preferred contact angle and the substrates having a preferred separation. In the case of many stripes, one has a whole sequence of morphological transitions with the number of bridges decreasing as the surface separation grows

The Influence of Substrate Structure on Membrane Adhesion

We consider a membrane both weakly and strongly adhering to a geometrically structured substrate. The interaction potential is assumed to be local, via the Deryagin approximation, and harmonic. Consequently, we can analytically describe a variety of different geometries: as well as randomly rough self-affine surfaces, smooth substrates interrupted by an isolated cylindrical pit, a single elongated trench or a periodic array of trenches are investigated. We present more general expressions for the adhesion energy and membrane configuration in Fourier space and find that, compared to planar surfaces, the adhesion energy decreases. We also highlight the possibility of overshoots occurring in the membrane profile and look at its degree of penetration into surface indentations.Comment: 41 pages LaTex, 12 EPS figure

Corrugation-Induced First-Order Wetting: An Effective Hamiltonian Study

We consider an effective Hamiltonian description of critical wetting transitions in systems with short-range forces at a corrugated (periodic) wall. We are able to recover the results obtained previously from a `microscopic' density-functional approach in which the system wets in a discontinuous manner when the amplitude of the corrugations reaches a critical size A*. Using the functional renormalization group, we find that A* becomes dependent on the wetting parameter \omega in such a way as to decrease the extent of the first-order regime. Nevertheless, we still expect wetting in the Ising model to proceed in a discontinuous manner for small deviations of the wall from the plane.Comment: 9 pages RevTex with 2 EPS figures. To appear in Eur. Phys. J.

An exact solution for two dimensional wetting with a corrugated wall

An exact solution of a two dimensional RSOS model of wetting at a corrugated (periodic) wall is found using transfer matrix techniques. In contrast to mean-field analysis of the same problem the wetting transition remains second-order and occurs at a lower temperature than that of the planar system. Comparison with numerical studies and other analytical approaches is made.Comment: 11 pages LaTex with 1 eps figure. To appear in J.Phys.

Coupled Hamiltonians and Three Dimensional Short-Range Wetting Transitions

We address three problems faced by effective interfacial Hamiltonian models of wetting based on a single collective coordinate \ell representing the position of the unbinding fluid interface. Problems (P1) and (P2) refer to the predictions of non-universality at the upper critical dimension d=3 at critical and complete wetting respectively which are not borne out by Ising model simulation studies. (P3) relates to mean-field correlation function structure in the underlying continuum Landau model. We investigate the hypothesis that these concerns arise due to the coupling of order parameter fluctuations near the unbinding interface and wall. For quite general choices of collective coordinates X_i we show that arbitrary two-field models H[X_1,X_2] can recover the required anomalous structure of mean-field correlation functions (P3). To go beyond mean-field theory we introduce a set of Hamiltonians based on proper collective coordinates s near the wall which have both interfacial and spin-like components. We argue that an optimum model H[s,\ell] in which the degree of coupling is controlled by an angle-like variable, best describes the non-universality of the Ising model and investigate its critical behaviour. For critical wetting the appropriate Ginzburg criterion shows that the true asymptotic critical regime for the local susceptibility \chi_1 is dramatically reduced consistent with observations of mean-field behaviour in simulations (P1). For complete wetting the model yields a precise expression for the temperature dependence of the renormalized critical amplitude \theta in good agreement with simulations (P2). We highlight the importance of a new wetting parameter which describes the physics that emerges due to the coupling effects.Comment: 34 pages, RevTex, 8 eps figures. To appear in Physica

Contextual classification of multispectral image data

There are no author-identified significant results in this report

Aerosil in Solid-state Buccal Film for Improved and Sustained Delivery of Valsartan: Molecular Docking Studies

To overcome low oral bioavailability and short biological half-life, improved and sustained buccal delivery of valsartan has been proposed. Valsartan film with colloidal silicon dioxide has been prepared using HPMC as mucoadhesive polymer matrix by casting and solvent evaporation method. Valsartan and Aerosil might have been interacted by hydrogen bond formation between adsorbed water and silanol of SiO2. In vitro drug release and ex vivo buccal permeation increased with the increase of Aerosil in the film. The formulation of valsartan to Aerosil at 1:0.02 ratio exhibited a sustained type of release and permeation of 80 and 70 %, respectively, in 8 h of study in simulated physiological fluid (pH 6.8). Molecular docking study revealed a stable configuration with favourable score of –2.15 kcal mol–1 of the Aerosil incorporated valsartan buccal film. In conclusion, Aerosil incorporated hydrogel forming buccal film could be used for improved and sustained delivery of valsartan. This work is licensed under a Creative Commons Attribution 4.0 International License

Two Parameters for Three Dimensional Wetting Transitions

Critical effects at complete and critical wetting in three dimensions are studied using a coupled effective Hamiltonian H[s(y),\ell]. The model is constructed via a novel variational principle which ensures that the choice of collective coordinate s(y) near the wall is optimal. We highlight the importance of a new wetting parameter \Omega(T) which has a strong influence on critical properties and allows the status of long-standing Monte-Carlo simulation controversies to be re-examined.Comment: 4 pages RevTex, 2 encapsulated postscript figures, to appear in Europhys. Let